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Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33AD251E mutation

11 Aug 2015

Abstract excerpt

The HOPS (homotypic fusion and protein sorting) complex functions in endocytic and autophagic pathways in both lower eukaryotes and mammalian cells through its involvement in fusion events between endosomes and lysosomes or autophagosomes and lysosomes. However, the differential molecular mechanisms underlying these fusion processes are largely unknown. Buff (bf) is a mouse mutant that carries an Asp251-to-Glu...

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PMID: 26259518
DOI: 10.1080/15548627.2015.1072669

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Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33AD251E mutationPMID 26259518Read ↗

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