Sepsis-Induced Thymic Atrophy Is Associated with Defects in Early Lymphopoiesis

Abstract excerpt

Impaired T lymphopoiesis is associated with immunosuppression of the adaptive immune response and plays a role in the morbidity and mortality of patients and animal models of sepsis. Although previous studies examined several intrathymic mechanisms that negatively affect T lymphopoiesis, the extrathymic mechanisms remain poorly understood. Here, we report a dramatic decrease in the percentage of early T lineage...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Clusterin in disease pathology
• Share to Lymphatic System and Diseases
• Share to Psoriasis: Treatment and Pathogenesis