Article
Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation.
PloS one - 1 Jan 2015
Zoch Ansgar, Mayerl Steffen, Schulz Alexander, Greither Thomas, Frappart Lucien, Rübsam Juliane, Heuer Heike, Giovannini Marco, Morrison Helen
Abstract excerpt
The tumour suppressor Merlin, encoded by the gene NF2, is frequently mutated in the autosomal dominant disorder neurofibromatosis type II, characterised primarily by the development of schwannoma and other glial cell tumours. However, NF2 is expressed in virtually all analysed human and rodent organs, and its deletion in mice causes early embryonic lethality. Additionally, NF2 encodes for two major isoforms of...
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