Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF2 Has Distinct Molecular Functions from GDNF in the Mouse Germline Niche.

Stem cell reports - 5 Jun 2018

Masaki Kaito, Sakai Mizuki, Kuroki Shunsuke, Jo Jun-Ichiro, Hoshina Kazuo, Fujimori Yuki, Oka Kenji, Amano Toshiyasu, Yamanaka Takahiro, Tachibana Makoto, Tabata Yasuhiko, Shiozawa Tanri, Ishizuka Osamu, Hochi Shinichi, Takashima Seiji

Abstract excerpt

Both glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells, whereas retinoic acid (RA) induces spermatogonial differentiation. In this study, we investigated the functional differences between FGF2 and GDNF in the germline niche by providing these factors using a drug delivery system in vivo. Although both factors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cell Self Renewal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 2

Share to Germ Cells

Share to Glial Cell Line-Derived Neurotrophic Factor

Share to Spermatogonia

Share to Stem Cell Niche

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 29681540
DOI: 10.1016/j.stemcr.2018.03.016
PMCID: PMC5989648

Genes

FGF2
GDNF
GFRA1
RARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF2 Has Distinct Molecular Functions from GDNF in the Mouse Germline Niche.PMID 29681540Read ↗

Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal.Semantic proximity Read ↗

Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent MannersSemantic proximity Read ↗

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteinsSemantic proximity Read ↗

NANOS2 Acts Downstream of Glial Cell Line-Derived Neurotrophic Factor Signaling to Suppress Differentiation of Spermatogonial Stem CellsSemantic proximity Read ↗

The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells.Semantic proximity Read ↗

Regulation of GDNF expression in Sertoli cellsSemantic proximity Read ↗

Regulation of spermatogonial stem cell self-renewal in mammals.Semantic proximity Read ↗

Gdnf signaling pathways within the mammalian spermatogonial stem cell nicheSemantic proximity Read ↗

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of<i>Etv5</i>and<i>Bcl6b</i>through MAP2K1 activationSemantic proximity Read ↗

Testicular endothelial cells are a critical population in the germline stem cell nicheSemantic proximity Read ↗

A long non-coding RNA interacts with Gfra1 and maintains survival of mouse spermatogonial stem cellsSemantic proximity Read ↗

Conservation of spermatogonial stem cell self-renewal signaling between mouse and ratSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.