The role of Drosophila Merlin in spermatogenesis

Abstract excerpt

BACKGROUND: Drosophila Merlin, the homolog of the human Neurofibromatosis 2 (NF2) gene, is important for the regulation of cell proliferation and receptor endocytosis. Male flies carrying a Mer3 allele, a missense mutation (Met177-->Ile) in the Merlin gene, are viable but sterile; however, the cause of sterility is unknown. RESULTS: Testis examination reveals that hemizygous Mer3 mutant males have small seminal...

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