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Article

GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2008

Jijiwa Mayumi, Kawai Kumi, Fukihara Jun, Nakamura Akari, Hasegawa Masaki, Suzuki Chikage, Sato Tomoko, Enomoto Atsushi, Asai Naoya, Murakumo Yoshiki, Takahashi Masahide

Abstract excerpt

Well-organized spermatogenesis, including the maintenance of spermatogonial stem cells (SSCs), is indispensable for continuous male fertility. Signaling by glial cell line-derived neurotrophic factor (GDNF) via the RET/GDNF family receptor alpha1 (GFRalpha1) receptor complex is essential for self-renewal of murine SSCs and may also regulate their differentiation. When phosphorylated, tyrosine 1062 in RET presents...

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Identifiers

PMID: 18363967
DOI: 10.1111/j.1365-2443.2008.01171.x

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RET
GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.PMID 18363967Read ↗

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