Article
Improved Detection of Microsatellite Instability in Early Colorectal Lesions.
PloS one - 1 Jan 2015
Bacher Jeffery W, Sievers Chelsie K, Albrecht Dawn M, Grimes Ian C, Weiss Jennifer M, Matkowskyj Kristina A, Agni Rashmi M, Vyazunova Irina, Clipson Linda, Storts Douglas R, Thliveris Andrew T, Halberg Richard B
Abstract excerpt
Microsatellite instability (MSI) occurs in over 90% of Lynch syndrome cancers and is considered a hallmark of the disease. MSI is an early event in colon tumor development, but screening polyps for MSI remains controversial because of reduced sensitivity compared to more advanced neoplasms. To increase sensitivity, we investigated the use of a novel type of marker consisting of long mononucleotide repeat (LMR)...
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