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Article

A functional variant in miR-143 promoter contributes to prostate cancer risk.

Archives of toxicology - 1 Feb 2016

Chu Haiyan, Zhong Dongyan, Tang Jialin, Li Jie, Xue Yao, Tong Na, Qin Chao, Yin Changjun, Zhang Zhengdong, Wang Meilin

Abstract excerpt

MicroRNAs are important regulators in numerous cellular processes, including cell differentiation, proliferation, and apoptosis. Recently, miR-143 was identified as a tumor suppressor in prostate cancer (PCa). To explore the mechanism of dysregulation and anti-tumor function of miR-143 in PCa, we first found a single-nucleotide polymorphism rs4705342T>C in the promoter region of miR-143 through bioinformatics...

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Identifiers

PMID: 25354797
DOI: 10.1007/s00204-014-1396-2

Genes

KLK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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