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Article

Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis.

PloS one - 1 Jan 2015

Lochhead Robert B, Zachary James F, Dalla Rosa Luciana, Ma Ying, Weis John H, O'Connell Ryan M, Weis Janis J

Abstract excerpt

MicroRNA-155 has been shown to play a role in immune activation and inflammation, and is suppressed by IL-10, an important anti-inflammatory cytokine. The established involvement of IL-10 in the murine model of Borrelia burgdorferi-induced Lyme arthritis and carditis allowed us to assess the interplay between IL-10 and miR-155 in vivo. As reported previously, Mir155 was highly upregulated in joints from infected...

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Source

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Identifiers

PMID: 26252010
DOI: 10.1371/journal.pone.0135142
PMCID: PMC4529177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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