Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of Macrophages

2 Mar 2016

Abstract excerpt

Macrophage infiltration is a hallmark feature of viral myocarditis. As studies have shown that microRNA-155 regulates the differentiation of macrophages, we aimed to investigate the role of microRNA-155 in VM. We report that silencing microRNA-155 protects mice from coxsackievirus B3 induced myocarditis. We found that microRNA-155 expression was upregulated and localized primarily in heart-infiltrating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to MicroRNA in disease regulation
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26931072
DOI: 10.1038/srep22613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of MacrophagesPMID 26931072Read ↗

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral MyocarditisSemantic proximity Read ↗

MicroRNA-30a-5p silencing polarizes macrophages toward M2 phenotype to alleviate cardiac injury following viral myocarditis by targeting SOCS1.Semantic proximity Read ↗

Long non-coding RNA AK085865 ablation confers susceptibility to viral myocarditis by regulating macrophage polarization.Semantic proximity Read ↗

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac InjurySemantic proximity Read ↗

lncRNA AK141955 Acts as a ceRNA to Regulate Macrophage Polarization via the miR-124-3p/Sema6d Axis in Viral MyocarditisSemantic proximity Read ↗

Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1Semantic proximity Read ↗

Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune responseSemantic proximity Read ↗

Control of the Inflammatory Macrophage Transcriptional Signature by miR-155.Semantic proximity Read ↗

Dysregulated CD4+ T Cells and microRNAs in MyocarditisSemantic proximity Read ↗

MicroRNAs Regulate the Pathogenesis of CVB3-Induced Viral MyocarditisSemantic proximity Read ↗

Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditisSemantic proximity Read ↗

Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.