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Article

Ex vivo culture of human fetal gonads: manipulation of meiosis signalling by retinoic acid treatment disrupts testis development.

Human reproduction (Oxford, England) - 1 Oct 2015

Jørgensen A, Nielsen J E, Perlman S, Lundvall L, Mitchell R T, Juul A, Rajpert-De Meyts E

Abstract excerpt

STUDY QUESTION: What are the effects of experimentally manipulating meiosis signalling by addition of retinoic acid (RA) in cultured human fetal gonads? SUMMARY ANSWER: RA-treatment accelerated meiotic entry in cultured fetal ovary samples, while addition of RA resulted in a dysgenetic gonadal phenotype in fetal testis cultures. WHAT IS KNOWN ALREADY: One of the first manifestations of sex differentiation is the...

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Identifiers

PMID: 26251460
DOI: 10.1093/humrep/dev194
PMCID: PMC5513102

Genes

AMH
DMRT1
FOXL2
SOX9
SRY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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