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Article

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.

Acta crystallographica. Section F, Structural biology communications - 1 Aug 2015

DiPisa Flavio, Pozzi Cecilia, Benvenuti Manuela, Andreini Matteo, Marconi Guido, Mangani Stefano

Abstract excerpt

Recent developments in molecular pathology and genetics have allowed the identification of human glutaminyl cyclase (hQC) among the abnormal proteins involved in many neurodegenerative disorders. Difficulties in obtaining large quantities of pure protein may limit the use of crystallographic screening for drug development on this target. Site-directed mutagenesis experiments have led to the identification of some...

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Identifiers

PMID: 26249687
DOI: 10.1107/S2053230X15010389
PMCID: PMC4528929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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