Article
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2005
Huang Kai-Fa, Liu Yi-Liang, Cheng Wei-Ju, Ko Tzu-Ping, Wang Andrew H-J
Abstract excerpt
N-terminal pyroglutamate (pGlu) formation from its glutaminyl (or glutamyl) precursor is required in the maturation of numerous bioactive peptides. The aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. This N-terminal cyclization reaction, once thought to proceed spontaneously, is greatly facilitated by the enzyme glutaminyl cyclase (QC)....
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