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Article

Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR.

Journal of the American Chemical Society - 26 Aug 2015

Moleschi Kody J, Akimoto Madoka, Melacini Giuseppe

Abstract excerpt

Allostery is a ubiquitous mechanism to control biological function and arises from the coupling of inhibitory and binding equilibria. The extent of coupling reflects the inactive vs active state selectivity of the allosteric effector. Hence, dissecting allosteric determinants requires quantification of state-specific association constants. However, observed association constants are typically population-averages,...

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Identifiers

PMID: 26247242
DOI: 10.1021/jacs.5b06557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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