Article
Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.
The Journal of biological chemistry - 12 Nov 2010
Diskar Mandy, Zenn Hans-Michael, Kaupisch Alexandra, Kaufholz Melanie, Brockmeyer Stefanie, Sohmen Daniel, Berrera Marco, Zaccolo Manuela, Boshart Michael, Herberg Friedrich W, Prinz Anke
Abstract excerpt
cAMP-dependent protein kinases are reversibly complexed with any of the four isoforms of regulatory (R) subunits, which contain either a substrate or a pseudosubstrate autoinhibitory domain. The human protein kinase X (PrKX) is an exemption as it is inhibited only by pseudosubstrate inhibitors, i.e. RIα or RIβ but not by substrate inhibitors RIIα or RIIβ. Detailed examination of the capacity of five PrKX-like...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Catalytic Domain
- Chlorocebus aethiops
- Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
- Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
- Cyclic AMP-Dependent Protein Kinases