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Article

Exploring allosteric coupling in the alpha-subunit of heterotrimeric G proteins using evolutionary and ensemble-based approaches.

BMC structural biology - 2 May 2008

Sayar Kemal, Uğur Ozlem, Liu Tong, Hilser Vincent J, Onaran Ongun

Abstract excerpt

BACKGROUND: Allosteric coupling, which can be defined as propagation of a perturbation at one region of the protein molecule (such as ligand binding) to distant sites in the same molecule, constitutes the most general mechanism of regulation of protein function. However, unlike molecular details...

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Identifiers

PMID: 18454845
DOI: 10.1186/1472-6807-8-23
PMCID: PMC2422842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18454845-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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