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Article

Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop.

Journal of molecular biology - 11 Feb 2005

Yang Jie, Garrod Siv M, Deal Michael S, Anand Ganesh S, Woods Virgil L, Taylor Susan

Abstract excerpt

Previous studies on the catalytic subunit of cAMP-dependent protein kinase (PKA) identified a conserved interaction pair comprised of Tyr204 from the P+1 loop and Glu230 at the end of the alphaF-helix. Single-point mutations of Tyr204 to Ala (Y204A) and Glu230 to Gln (E230Q) both resulted in alterations in enzymatic kinetics. To understand further the molecular basis for the altered kinetics and the structural...

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Identifiers

PMID: 15663937
DOI: 10.1016/j.jmb.2004.11.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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