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Article

Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.

Journal of virology - 1 Oct 2015

Falson Pierre, Bartosch Birke, Alsaleh Khaled, Tews Birke Andrea, Loquet Antoine, Ciczora Yann, Riva Laura, Montigny Cédric, Montpellier Claire, Duverlie Gilles, Pécheur Eve-Isabelle, le Maire Marc, Cosset François-Loïc, Dubuisson Jean, Penin François

Abstract excerpt

UNLABELLED: In hepatitis C virus (HCV)-infected cells, the envelope glycoproteins E1 and E2 assemble as a heterodimer. To investigate potential changes in the oligomerization of virion-associated envelope proteins, we performed SDS-PAGE under reducing conditions but without thermal denaturation. This revealed the presence of SDS-resistant trimers of E1 in the context of cell-cultured HCV (HCVcc) as well as in the...

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PMID: 26246575
DOI: 10.1128/JVI.00991-15
PMCID: PMC4580159

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