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Article

CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche.

Cell and tissue research - 1 Dec 2015

Yokohama-Tamaki Tamaki, Otsu Keishi, Harada Hidemitsu, Shibata Shunichi, Obara Nobuko, Irie Kazuharu, Taniguchi Akiyoshi, Nagasawa Takashi, Aoki Kazunari, Caliari Steven R, Weisgerber Daniel W, Harley Brendan A C

Abstract excerpt

Dental stem cells are located at the proximal ends of rodent incisors. These stem cells reside in the dental epithelial stem cell niche, termed the apical bud. We focused on identifying critical features of a chemotactic signal in the niche. Here, we report that CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in dental stem cell niche cells. We report cells in the apical bud...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26246398
DOI: 10.1007/s00441-015-2248-y
PMCID: PMC4679681

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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