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Article

The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2016

Otsu Keishi, Ida-Yonemochi Hiroko, Fujiwara Naoki, Harada Hidemitsu

Abstract excerpt

During tooth development, oral epithelial cells differentiate into ameloblasts in order to form the most mineralized tissue in the vertebrate body: enamel. During this process, ameloblasts directionally secrete enamel matrix proteins and morphologically change from low columnar cells to polarized tall columnar cells, both of which are essential for the proper formation of enamel. In this study, we elucidated the...

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PMID: 27218883
DOI: 10.1002/jbmr.2876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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