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Article

The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2016

Otsu Keishi, Ida-Yonemochi Hiroko, Fujiwara Naoki, Harada Hidemitsu

Abstract excerpt

During tooth development, oral epithelial cells differentiate into ameloblasts in order to form the most mineralized tissue in the vertebrate body: enamel. During this process, ameloblasts directionally secrete enamel matrix proteins and morphologically change from low columnar cells to polarized...

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Source

Identifiers

PMID: 27218883
DOI: 10.1002/jbmr.2876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-27218883-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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