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Article

Autoimmune disease-associated haplotypes of BLK exhibit lowered thresholds for B cell activation and expansion of Ig class-switched B cells.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Nov 2015

Simpfendorfer Kim R, Armstead Brandon E, Shih Andrew, Li Wentian, Curran Mark, Manjarrez-Orduño Nataly, Lee Annette T, Diamond Betty, Gregersen Peter K

Abstract excerpt

OBJECTIVE: B lymphoid kinase (BLK) is associated with rheumatoid arthritis (RA) and several other B cell-associated autoimmune disorders. BLK risk variants are consistently associated with reduced BLK expression, but the mechanisms by which reduced expression alters human B cell function to confer autoimmune disease susceptibility are unknown. This study was undertaken to characterize the BLK risk haplotype and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26246128
DOI: 10.1002/art.39301

Genes

BLK
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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