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Article

Spinophilin Is Indispensable for the α2B Adrenergic Receptor-Elicited Hypertensive Response.

PloS one - 1 Jan 2015

Che Pulin, Chen Yunjia, Lu Roujian, Peng Ning, Gannon Mary, Wyss J Michael, Jiao Kai, Wang Qin

Abstract excerpt

The α2 adrenergic receptor (AR) subtypes are important for blood pressure control. When activated, the α2A subtype elicits a hypotensive response whereas the α2B subtype mediates a hypertensive effect that counteracts the hypotensive response by the α2A subtype. We have previously shown that spinophilin attenuates the α2AAR-dependent hypotensive response; in spinophilin null mice, this response is highly...

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Identifiers

PMID: 26244553
DOI: 10.1371/journal.pone.0135030
PMCID: PMC4526467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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