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Validation of a semiconductor next‐generation sequencing‐based protocol for preimplantation genetic diagnosis of reciprocal translocations

4 Aug 2015

Abstract excerpt

OBJECTIVE: We aim to validate a semiconductor next-generation sequencing (NGS)-based method to detect unbalanced chromosome translocation in preimplantation embryos. METHODS: The study consisted of a blinded retrospective evaluation with NGS of 145 whole-genome amplification products obtained from biopsy of cleavage-stage embryos or blastocysts, derived from 33 couples carrying different balanced translocations....

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PMID: 26243475
DOI: 10.1002/pd.4665

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