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Validation of Copy Number Variation Sequencing for Detecting Chromosome Imbalances in Human Preimplantation Embryos1

26 Jun 2014

Abstract excerpt

Chromosome aneuploidies commonly arise in embryos produced by assisted reproductive technologies and represent a major cause of implantation failure and miscarriage. Currently, preimplantation genetic diagnosis (PGD) is performed by array-based methods to identify euploid embryos for transfer to the patient. We speculated that a combination of next-generation sequencing technologies and sophisticated...

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Share to Genetic Syndromes and Imprinting
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PMID: 24966395
DOI: 10.1095/biolreprod.114.120576

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