Article
Kinin-B1 and B2 receptor activity in proliferation and neural phenotype determination of mouse embryonic stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 Nov 2015
Nascimento Isis C, Glaser Talita, Nery Arthur A, Pillat Micheli M, Pesquero João B, Ulrich Henning
Abstract excerpt
The kinins bradykinin and des-arg(9) -bradykinin cleaved from kininogen precursors by kallikreins exert their biological actions by stimulating kinin-B2 and B1 receptors, respectively. In vitro models of neural differentiation such as P19 embryonal carcinoma cells and neural progenitor cells have suggested the involvement of B2 receptors in neural differentiation and phenotype determination; however, the...
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