Article
Tributyltin differentially promotes development of a phenotypically distinct adipocyte.
Obesity (Silver Spring, Md.) - 1 Sept 2015
Regnier Shane M, El-Hashani Essam, Kamau Wakanene, Zhang Xiaojie, Massad Nicole L, Sargis Robert M
Abstract excerpt
OBJECTIVE: Environmental endocrine disrupting chemicals (EDCs) are increasingly implicated in the pathogenesis of obesity. Evidence implicates various EDCs as being proadipogenic, including tributyltin (TBT), which activates the peroxisome proliferator activated receptor-γ (PPARγ). However, the conditions required for TBT-induced adipogenesis and its functional consequences are incompletely known. METHODS: The...
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