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Article

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.

Biochimica et biophysica acta - 1 Jun 2016

Longo Michele, Spinelli Rosa, D'Esposito Vittoria, Zatterale Federica, Fiory Francesca, Nigro Cecilia, Raciti Gregory A, Miele Claudia, Formisano Pietro, Beguinot Francesco, Di Jeso Bruno

Abstract excerpt

Adipocyte differentiation is critical in obesity. By controlling new adipocyte recruitment, adipogenesis contrasts adipocyte hypertrophy and its adverse consequences, such as insulin resistance. Contrasting data are present in literature on the effect of endoplasmic reticulum (ER) stress and subsequent unfolded protein response (UPR) on adipocyte differentiation, being reported to be either necessary or...

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PMID: 26940722
DOI: 10.1016/j.bbamcr.2016.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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