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Article

Mitochondria DNA Replication and DNA Methylation in the Metabolic Memory Associated with Continued Progression of Diabetic Retinopathy

29 Jun 2012

Abstract excerpt

PURPOSE: Diabetic retinopathy fails to halt after cessation of hyperglycemic insult, and a vicious cycle of mitochondria damage continues. The aim of our study was to investigate the effect of termination of hyperglycemia on retinal mtDNA replication, and elucidate the mechanism responsible for the continued mtDNA damage. METHODS: Polymerase gamma 1 (POLG1), the catalytic subunit of the mitochondrial DNA...

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PMID: 22743328
DOI: 10.1167/iovs.12-9732

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