Article
Ancient hot and cold genes and chemotherapy resistance emergence.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015
Wu Amy, Zhang Qiucen, Lambert Guillaume, Khin Zayar, Gatenby Robert A, Kim Hyunsung John, Pourmand Nader, Bussey Kimberly, Davies Paul C W, Sturm James C, Austin Robert H
Abstract excerpt
We use a microfabricated ecology with a doxorubicin gradient and population fragmentation to produce a strong Darwinian selective pressure that drives forward the rapid emergence of doxorubicin resistance in multiple myeloma (MM) cancer cells. RNA sequencing of the resistant cells was used to examine (i) emergence of genes with high de novo substitution densities (i.e., hot genes) and (ii) genes never substituted...
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