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Article

Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/β-catenin signaling

27 Jul 2015

Abstract excerpt

The primary function of white adipose tissues is to store excess energy. The current study aimed to investigate the roles of Gremlin 2 (Grem2), a glycoprotein in adipogenesis. Using polymerase chain reaction‑based microarrays, it was determined that Grem2 was markedly downregulated in adipose tissues from obese animals and humans. In addition, 3T3‑L1 cells were used to investigate the details of the mechanisms...

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PMID: 26239165
DOI: 10.3892/mmr.2015.4117

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