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Article

Circulating 4-F4t-Neuroprostane and 10-F4t-Neuroprostane Are Related to MECP2 Gene Mutation and Natural History in Rett Syndrome.

International journal of molecular sciences - 19 Apr 2021

Signorini Cinzia, Leoncini Silvia, Durand Thierry, Galano Jean-Marie, Guy Alexandre, Bultel-Poncé Valérie, Oger Camille, Lee Jetty Chung-Yung, Ciccoli Lucia, Hayek Joussef, De Felice Claudio

Abstract excerpt

Neuroprostanes, a family of non-enzymatic metabolites of the docosahexaenoic acid, have been suggested as potential biomarkers for neurological diseases. Objective biological markers are strongly needed in Rett syndrome (RTT), which is a progressive X-linked neurodevelopmental disorder that is mainly caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene with a predominant multisystemic phenotype....

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Identifiers

PMID: 33921863
DOI: 10.3390/ijms22084240
PMCID: PMC8073126

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