Article
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.
Nature communications - 3 Aug 2015
He Shanshan, Zhao Zhen, Yang Yongfei, O'Connell Douglas, Zhang Xiaowei, Oh Soohwan, Ma Binyun, Lee Joo-Hyung, Zhang Tian, Varghese Bino, Yip Janae, Dolatshahi Pirooz Sara, Li Ming, Zhang Yong, Li Guo-Min, Ellen Martin Sue, Machida Keigo, Liang Chengyu
Abstract excerpt
Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated in common human cancers. Here we demonstrate that the cancer-related UVRAG frameshift (FS), which does not result in a...
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