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Article

UVRAG: A New Player in Autophagy and Tumor Cell Growth

8 Jan 2007

Abstract excerpt

Autophagy has a well-documented role in the maintenance of homeostasis and the response to stressful environments and it is often deregulated in various human diseases including cancer. The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway. Previous studies1 have demonstrated that Beclin 1-PI3KC3-mediated autophagy is negatively regulated by a...

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Identifiers

PMID: 17106237
DOI: 10.4161/auto.3437

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