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Frameshift mutations of autophagy‐related genes <i>ATG2B, ATG5, ATG9B</i> and <i>ATG12</i> in gastric and colorectal cancers with microsatellite instability

23 Dec 2008

Abstract excerpt

Mounting evidence indicates that alterations of autophagy processes are directly involved in the development of many human diseases, including cancers. Autophagy-related gene (ATG) products are main players in the autophagy process. In humans there are 16 known ATG genes, of which four (ATG2B, ATG5, ATG9B and ATG12) have mononucleotide repeats with seven or more nucleotides. Frameshift mutations of genes with...

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PMID: 19197948
DOI: 10.1002/path.2509

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