Article
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.
Nature communications - 12 Dec 2019
Quach Christine, Song Ying, Guo Hongrui, Li Shun, Maazi Hadi, Fung Marshall, Sands Nathaniel, O'Connell Douglas, Restrepo-Vassalli Sara, Chai Billy, Nemecio Dali, Punj Vasu, Akbari Omid, Idos Gregory E, Mumenthaler Shannon M, Wu Nancy, Martin Sue Ellen, Hagiya Ashley, Hicks James, Cui Hengmin, Liang Chengyu
Abstract excerpt
Aberrant autophagy is a major risk factor for inflammatory diseases and cancer. However, the genetic basis and underlying mechanisms are less established. UVRAG is a tumor suppressor candidate involved in autophagy, which is truncated in cancers by a frameshift (FS) mutation and expressed as a shortened UVRAGFS. To investigate the role of UVRAGFS in vivo, we generated mutant mice that inducibly express UVRAGFS...
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