Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.

Autophagy - 1 Oct 2010

Knævelsrud Helene, Ahlquist Terje, Merok Marianne A, Nesbakken Arild, Stenmark Harald, Lothe Ragnhild A, Simonsen Anne

Abstract excerpt

Reduced levels of autophagy correlate with tumorigenesis, and several inducers of autophagy have been found to be tumor suppressors. One such autophagic inducer is the Beclin 1 binding protein UVRAG, a positive regulator of the class III PI3K/Vps34 complex. UVRAG has been implicated in the formation and maturation of autophagosomes, as well as in endocytic trafficking and suppression of proliferation and in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Microsatellite Instability

Share to Mutation

Share to Recombinant Fusion Proteins

Share to RNA, Small Interfering

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 20724836
DOI: 10.4161/auto.6.7.13033

Genes

UVRAG
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.PMID 20724836Read ↗

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.Semantic proximity Read ↗

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instabilitySemantic proximity Read ↗

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.Semantic proximity Read ↗

Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours.Semantic proximity Read ↗

Frameshift mutations of autophagy‐related genes <i>ATG2B, ATG5, ATG9B</i> and <i>ATG12</i> in gastric and colorectal cancers with microsatellite instabilitySemantic proximity Read ↗

An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.Semantic proximity Read ↗

KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers.Semantic proximity Read ↗

Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.