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Article

Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Aug 2015

Banda Malathi, McKim Karen L, Haber Lynne T, MacGregor Judith A, Gollapudi B Bhaskar, Parsons Barbara L

Abstract excerpt

This study investigated whether Kras mutation is an early event in the development of lung tumors induced by inhalation of particulate vanadium pentoxide (VP) aerosols. A National Toxicology Program tumor bioassay of inhaled particulate VP aerosols established that VP-induced alveolar/bronchiolar carcinomas of the B6C3F1 mouse lung carried Kras mutations at a higher frequency than observed in spontaneous mouse...

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Identifiers

PMID: 26232258
DOI: 10.1016/j.mrgentox.2015.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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