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Article

Cuproptosis engages in c-Myc-mediated breast cancer stemness.

Journal of translational medicine - 23 Jun 2023

Wang Runtian, Xu Kun, Chen Qin, Hu Qin, Zhang Jian, Guan Xiaoxiang

Abstract excerpt

BACKGROUND: Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it is of great significance to investigate and even target the regulatory factors driving intra-tumoral stemness. c-Myc is a vital oncogene frequently overexpressed or amplified in various cancer types, including breast cancer. Our previous study...

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Identifiers

PMID: 37353799
DOI: 10.1186/s12967-023-04204-5
PMCID: PMC10288777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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