Article
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Molecular cancer - 31 Jul 2015
Sandercock Alan M, Rust Steven, Guillard Sandrine, Sachsenmeier Kris F, Holoweckyj Nick, Hay Carl, Flynn Matt, Huang Qihui, Yan Kuan, Herpers Bram, Price Leo S, Soden Jo, Freeth Jim, Jermutus Lutz, Hollingsworth Robert, Minter Ralph
Abstract excerpt
BACKGROUND: Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of clinical outcome. In this study, we describe a phenotypic antibody screen using three-dimensional cultures of primary cells, and image-based...
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