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Deep Learning-Driven TCRβ Repertoire Analysis Enhances Diagnosis and Enables Mining of Immunological Biomarkers in Systemic Lupus Erythematosus

2025-05-02

Abstract excerpt

<title>Abstract</title> <p>Background Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder characterized by abnormal T-cell responses, which significantly contribute to the disease’s immune pathology. The Complementarity Determining Region 3 (CDR3) of the TCRβ chain is pivotal for T-cell specificity, thereby positioning it as a promising target for enhancing diagnostic accuracy and gaining deeper m...

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Literature Corpus work: c5e69b11-9a22-5316-8a13-edaacbaeadb3
DOI: 10.21203/rs.3.rs-6327711/v1

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