Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS

30 Jul 2015

Abstract excerpt

BACKGROUND: There is growing evidence that microglia are key players in the pathological process of amyotrophic lateral sclerosis (ALS). It is suggested that microglia have a dual role in motoneurone degeneration through the release of both neuroprotective and neurotoxic factors. RESULTS: To identify candidate genes that may be involved in ALS pathology we have analysed at early symptomatic age (P90), the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Cervical and Thoracic Myelopathy
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26227626
DOI: 10.1186/s13024-015-0023-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALSPMID 26227626Read ↗

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse ModelSemantic proximity Read ↗

ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progressionSemantic proximity Read ↗

A core transcriptional signature of human microglia: Derivation and utility in describing region‐dependent alterations associated with Alzheimer's diseaseSemantic proximity Read ↗

A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer's diseaseSemantic proximity Read ↗

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.Semantic proximity Read ↗

HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseasesSemantic proximity Read ↗

A CAR-T Cell-Based Strategy for Eliminating Pathogenic Microglia in ALSSemantic proximity Read ↗

Defective phagocytic function of induced microglia-like cells is correlated with rapid progression of sporadic ALSSemantic proximity Read ↗

Microglia replacement effectively attenuates the disease progress of ALSP in the mouse model and human patientSemantic proximity Read ↗

Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cordSemantic proximity Read ↗

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.Semantic proximity Read ↗

Transcriptomic and functional analysis of Aβ <sub>1-42</sub> oligomer-stimulated human monocyte-derived microglia-like cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.