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Article

SOD1 aggregation in ALS mice shows simplistic test tube behavior.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015

Lang Lisa, Zetterström Per, Brännström Thomas, Marklund Stefan L, Danielsson Jens, Oliveberg Mikael

Abstract excerpt

A longstanding challenge in studies of neurodegenerative disease has been that the pathologic protein aggregates in live tissue are not amenable to structural and kinetic analysis by conventional methods. The situation is put in focus by the current progress in demarcating protein aggregation in vitro, exposing new mechanistic details that are now calling for quantitative in vivo comparison. In this study, we...

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Source

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Identifiers

PMID: 26221023
DOI: 10.1073/pnas.1503328112
PMCID: PMC4538623

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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