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Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping

23 Mar 2015

Abstract excerpt

Despite considerable progress in uncovering the molecular details of protein aggregation in vitro, the cause and mechanism of protein-aggregation disease remain poorly understood. One reason is that the amount of pathological aggregates in neural tissue is exceedingly low, precluding examination by conventional approaches. We present here a method for determination of the structure and quantity of aggregates in...

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PMID: 25802384
DOI: 10.1073/pnas.1419228112

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