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Cellular Gene Expression during Hepatitis C Virus Replication as Revealed by Ribosome Profiling

15 Mar 2019

Abstract excerpt

Background: Hepatitis C virus (HCV) infects human liver hepatocytes, often leading to liver cirrhosis and hepatocellular carcinoma (HCC). It is believed that chronic infection alters host gene expression and favors HCC development. In particular, HCV replication in Endoplasmic Reticulum (ER) derived membranes induces chronic ER stress. How HCV replication affects host mRNA translation and transcription at a...

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PMID: 30875926
DOI: 10.3390/ijms20061321

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