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Article

Powerful Rare-Variant Association Analysis of Secondary Phenotypes.

Genetic epidemiology - 1 Jan 2025

Liu Hanyun, Zhang Hong

Abstract excerpt

Most genome-wide association studies are based on case-control designs, which provide abundant resources for secondary phenotype analyses. However, such studies suffer from biased sampling of primary phenotypes, and the traditional statistical methods can lead to seriously distorted analysis results when they are applied to secondary phenotypes without accounting for the biased sampling mechanism. To our...

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PMID: 39350332
DOI: 10.1002/gepi.22589

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