Article
Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.
Blood - 1 Nov 2008
Iacobucci Ilaria, Lonetti Annalisa, Messa Francesca, Cilloni Daniela, Arruga Francesca, Ottaviani Emanuela, Paolini Stefania, Papayannidis Cristina, Piccaluga Pier Paolo, Giannoulia Panagiota, Soverini Simona, Amabile Marilina, Poerio Angela, Saglio Giuseppe, Pane Fabrizio, Berton Giorgio, Baruzzi Anna, Vitale Antonella, Chiaretti Sabina, Perini Giovanni, Foà Robin, Baccarani Michele, Martinelli Giovanni
Abstract excerpt
Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages. The expression of short isoforms lacking DNA-binding motifs alters the differentiation capacities of hematopoietic progenitors, arresting lineage commitment. We sought to determine whether molecular abnormalities involving the IKZF1 gene were associated with resistance to tyrosine kinase inhibitors (TKIs)...
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