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Article

Arg25Pro (c.915G>C) polymorphism of transforming growth factor β1 gene increases the risk of developing Graves' disease.

International immunopharmacology - 1 Jun 2014

Doğru-Abbasoğlu Semra, Vural Pervin, Baki Merve, Özderya Ayşenur, Karadağ Berrin, Uysal Müjdat

Abstract excerpt

BACKGROUND: Graves' disease (GD) arises due to complex interactions between genetic and environmental factors. Transforming growth factor β1 (TGFβ1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, thyroid follicular cell hyperplasia, and production of autoantibody in the thyroid gland of patients with GD. AIM: The aim of the present study was to investigate the possible...

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PMID: 24742542
DOI: 10.1016/j.intimp.2014.03.019

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