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Article

The phasevarion: a genetic system controlling coordinated, random switching of expression of multiple genes.

Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2005

Srikhanta Yogitha N, Maguire Tina L, Stacey Katryn J, Grimmond Sean M, Jennings Michael P

Abstract excerpt

Several host-adapted bacterial pathogens contain methyltransferases associated with type III restriction-modification (R-M) systems that are subject to reversible, high-frequency on/off switching of expression (phase variation). To investigate the role of phase-variable expression of R-M systems, we made a mutant strain lacking the methyltransferase (mod) associated with a type III R-M system of Haemophilus...

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Identifiers

PMID: 15802471
DOI: 10.1073/pnas.0501169102
PMCID: PMC556257

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Source receipt: pubmed, retrieved 7 Sept 2026.

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