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ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media

2 Sept 2014

Abstract excerpt

Moraxella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we characterize a phase‐variable DNA methyltransferase (ModM), which contains 5′‐CAAC‐3′ repeats in its open reading frame that mediate high‐frequency mutation resulting in reversible on/off switching of ModM expression. Three modM alleles have been identified ( modM1–3 ), with modM2...

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PMID: 25183669
DOI: 10.1096/fj.14-256578

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