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ModA2 Phasevarion Switching in Nontypeable<i>Haemophilus influenzae</i>Increases the Severity of Experimental Otitis Media

10 Jun 2016

Abstract excerpt

Several human-adapted bacterial pathogens use a phasevarion (ie, a phase-variable regulon) to rapidly and reversibly regulate the expression of many genes, which include known virulence factors, yet the influence of phasevarion-mediated regulation in pathogenesis remains poorly understood. Here we examine the impact of the nontypeable Haemophilus influenzae (NTHI) ModA2 phasevarion on pathogenesis and disease...

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PMID: 27288538
DOI: 10.1093/infdis/jiw243

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